How ScanOFe Works

From abnormal finding
to actionable intelligence

ScanOFe does not replace clinical judgment. It accelerates it. When a clinician identifies an abnormal finding, ScanOFe takes over the cognitive load of syndromic reasoning, presenting ranked differentials, associated genes, and targeted investigation pathways in real time.

Finding-driven, not image-driven Gestation-aware logic No re-interpretation of images

Three Integrated Modes

One platform, three clinical workflows

ScanOFe is designed around the three decision points that matter most in a fetal medicine consultation: interpreting what you found, anticipating what you might find, and documenting it correctly.

01 / Forward Mode

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Findings → Syndrome Intelligence

Enter one or more abnormal ultrasound findings. ScanOFe presents ranked syndrome differentials, associated gene panels, and targeted investigations. Structured by clinical priority.

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02 / Reverse Mode

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Syndrome → Ultrasound Checklist

Search by suspected syndrome or confirmed genetic condition. ScanOFe maps the expected prenatal phenotype. What to look for, at which gestational age, and in which organ systems.

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03 / Reporting Module

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Structured Report Generation

Generate scan reports with embedded growth curves, Doppler charts, and counseling notes. Templates cover FTS, anomaly scan, and third-trimester surveillance with risk stratification output.

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01. Forward Mode

When the scan shows something unexpected

Forward Mode is the primary workflow. When a clinician identifies one or more abnormal findings. A measurement below the 5th centile, a structural anomaly, an unexpected Doppler pattern. They enter those findings into ScanOFe and receive a prioritised, structured differential.

Clinical Scenario

"18-week anomaly scan. Agenesis of the corpus callosum detected with borderline ventriculomegaly and a small cerebellar vermis. Patient has no prior genetic history." → Enter 3 findings. ScanOFe returns ranked syndrome differentials, gene panels to consider, and whether chromosomal microarray alone is sufficient or exome is warranted.

Step 1. Enter abnormal findings

Select findings from a structured menu of fetal anatomy systems. Measurements trigger automatic centile alerts (<5th / >95th) with gestation-adjusted reference ranges.

Step 2. Receive ranked differentials

ScanOFe presents possible malformations first, then ranked syndrome associations. Rankings weight gestation, co-occurrence patterns, and phenotype prevalence in prenatal populations.

Syndrome matches Prevalence weighting Co-occurrence logic

Step 3. Gene and investigation pathway

For each syndrome candidate: associated causative genes, recommended gene panels, and when exome sequencing is clinically justified versus unnecessary.

Step 4. Risk stratification and management

Risk level, suggested next steps, and counseling framework. Integrated into the reporting module for documentation.

Findings input → ranked syndrome differentials → gene and investigation pathway. All in a single interface without leaving the reporting workflow.

What ScanOFe does not do. And why that matters

ScanOFe never re-interprets ultrasound images. It never tells the clinician their finding is wrong. It never generates a diagnosis. It works with what the clinician has already identified and extends the thinking from that point. This design decision is not a limitation. It is a deliberate clinical philosophy.

ScanOFe accepts

Clinician-entered findings

Structural anomalies identified on scan

Measurement data and centile flags

Doppler waveform classifications

Known or suspected syndrome

ScanOFe generates

Ranked syndrome differentials

Phenotype maps for each syndrome

Gene-level linkage and panel guidance

Investigation recommendations

Structured scan reports

ScanOFe never does

Interpret raw ultrasound images

Override clinician findings

Generate a standalone diagnosis

Replace clinical judgment

Make treatment decisions

02. Reverse Mode

When you suspect a syndrome. Confirm what to look for

Reverse Mode addresses the second major clinical scenario: you have a suspected or confirmed genetic diagnosis. Perhaps from NIPT, family history, or prior pregnancy. And you need to know exactly what the ultrasound should show, and at what gestational age.

Clinical Scenario

"NIPT returns high-risk for Trisomy 18. Patient is 13 weeks. Detailed anatomy scan planned for 16 weeks." → Enter Trisomy 18 in Reverse Mode. ScanOFe returns a prenatal phenotype checklist: AVSD, choroid plexus cysts, rocker-bottom feet, overlapping fingers, IUGR pattern. With gestational age notes on when each finding is likely to become sonographically visible.

Step 1. Search by syndrome or condition

Enter a syndrome name, gene, chromosomal condition, or partial phenotype. ScanOFe searches a prenatal-specific database built from fetal medicine literature, not general genomics resources.

Step 2. Retrieve prenatal phenotype map

For each syndrome: the expected ultrasound markers, organised by anatomy system. Each marker includes gestational timing. When it typically becomes visible, and at what level of confidence.

Organ-system organised Gestational timing Detection confidence

Step 3. Missed-finding alerts

ScanOFe highlights findings that are frequently missed or seen only in specific gestational windows. Reducing the risk of incomplete phenotyping.

Syndrome search returns a prenatal phenotype map: what to look for, in which system, and at which gestational age. With missed-finding alerts.

03. Reporting Module

Structured documentation built into the workflow

The Reporting Module generates structured scan reports from within the same session. No copy-pasting, no parallel documentation. Growth curves, Doppler charts, risk stratification output, and counseling notes are embedded in the report directly from the clinical session.

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FTS. First Trimester Screening

NT, NB, ductus venosus, tricuspid regurgitation. Risk calculations for T21, T18, T13. Integrates with FMF risk model output.

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Anomaly Scan. Second Trimester

Systematic anatomy documentation by organ system. Auto-flags abnormal measurements. Populates syndrome intelligence from Forward Mode directly.

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Third Trimester. Growth & Doppler

Growth velocity tracking, Doppler waveform classification (UA, MCA, DV), FGR staging with color-coded alerts. Preeclampsia risk stratification.

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Counseling Notes Section

Add free-text clinical notes and structured counseling documentation directly into the report. Printable with growth curves embedded.

ScanOFe Report: 3rd Trimester structured report with patient information, dating and pregnancy details

Reports are generated within the session. Growth curves, Doppler charts, risk output, and counseling notes are embedded directly. Print-ready output.

Deployment & Integration

Works with your existing setup

ScanOFe is platform-agnostic. It runs in any modern browser, on any operating system. No proprietary hardware, no software installation required. Access it from the reporting workstation beside the machine or from a tablet in the scan room.

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Desktop & Laptop

Windows, macOS, Linux. Browser-based

  • Full ScanOFe interface alongside your reporting station
  • No software installation required. Browser access only
  • Works with any EMR or reporting system open in parallel
  • Consistent interface across operating systems
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Tablet. Near-Machine Access

iPad, Android tablet. Any modern browser

  • Use ScanOFe in the scan room while the patient is present
  • Touch-optimised interface for anatomy system navigation
  • DICOM transfer: ultrasound measurements auto-populate from machine
  • Ideal for direct clinician use during the consultation
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Ultrasound Machine Integration

Samsung, GE, Mindray, Sonoscape

  • DICOM structured report support for measurement transfer
  • Auto-populates biometry measurements into ScanOFe fields
  • NT, NB, fetal biometry, and Doppler values transferred directly
  • Reduces transcription errors in measurement-based analysis
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Cloud-Based Access

No local data storage required

  • Access from any internet-connected device
  • Institutional accounts with multi-user access management
  • Data privacy compliance. No patient data leaves your network
  • Regular knowledge base updates without software re-deployment

Clinical Intelligence Layer

Why gestation-aware logic matters

A finding at 13 weeks carries different differential weight than the same finding at 22 weeks. Most clinical databases are not designed with this distinction built in. ScanOFe's knowledge base is structured around gestational timing. The same way a fetal medicine specialist thinks.

First Trimester (11–14 weeks)

NT, NB, ductus venosus, tricuspid regurgitation, early structural markers. ScanOFe applies FTS-specific phenotype weighting and integrates first trimester risk calculator output.

Second Trimester (18–24 weeks)

Full structural anatomy scan. Syndrome phenotypes have the highest resolution at this stage. Forward Mode applies anomaly-scan-specific weights to differential rankings.

Third Trimester (28+ weeks)

Growth surveillance, FGR classification, Doppler staging, preeclampsia risk. Late-presenting anomalies. ScanOFe flags which findings require reassessment at this stage.

See it in a real clinical scenario

We run 30-minute demo sessions with your actual scan protocol. Anomaly scan, FTS, or complex case. No slides, no product tour. Just the tool running through a real workflow.

Book a Demo → For Clinicians